Thanks for that Sarah, pretty much explains what I wanted to know. I guess the good thing about BRP is that it's very much a "building blocks " kind of game. That is you can add stuff on and make it as complicated or as easy as you like.
So, you could easily have some kind of disease that affected the characters balance or some such, simply do a POT vs CON check and then subtract POTx5% from all agility skills ( or something similiar ). It's never going to kill the character in itself, but try crossing that rickety rope bridge over a crocodile infested ravine .......
