I played in a ong-running RQ2 campaign years ago, where we got up to the 100-150% range. The system held up just fine, we had fun, and didn't even know 100 was any sort of barrier...
These days, I run a BRP-like homebrew where plenty of characters (in one group) have 100%+ skills (weapons mainly), and it also works fine at those levels (it's the characters with under 100% I worry about...).
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