One thing that you have to watch when setting weapon damages is making them _too_ robust. Handguns kill people, and do so regularly, but people also eat four or five shots and keep coming; rifle rounds are more reliable, but people still survive being shot with rifles (and even .50 caliber machine guns). That's why I suspect keeping the damage somewhat modest and expecting impales to make up the difference is going to work better than getting too carried away with base damage.
Of course you also run into some problems where what works in a system using hit locations won't work in one that doesn't; in practice our black powder rules are much more deadly in RQ than they'd be in most versions of BRP.
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