Well, I did say I would like to see a "scrubbed" down version of the Sanity rules. I think that some of CoC Sanity effects would be over the top for other genres and styles, but are fitting to that style and genre.
It would something along the lines of minor phobias and quirks are gained by the character. Let's face it, unless the gamer is experienced and a roleplaying focused person, then most run-of-the-mill gamers aren't going to add something "bad" or negative to their precious character, LOL.
I agree that sci-fi campaign settings just are not a money-maker for the RPG industry like generic fantasy settings. Too bad.