I really like the Cthulhu Rising setting. Its a great read and there are several adventures and campaigns for it. Years ago I played a series of adventures with a cthulhoid taint in the 2300AD setting and CT remembers me alot of these games. I would be very pleased if CT becomes something more "official".
At the moment there are no real good blends between Scifi and Cthulhoid horror. But the mix is very attractive I think. The more contrast is between the "real world" and the "horror world" the better. I would not like a gothic SF horror game that much as CT. But the harder the SF the better. Mongoose has one genre mix in its pipeline called Cthulhutech which looks....well...bad and pulpy.
Additionally you can always play CT as hard SF game without horror elements, but with BRP rules. (ala Bladerunner, Outland or Aliens)