The drawback to gates is like Triff said. Little cooperation. Basically, unless the gates are well known and there is a lot of commerce and interaction between the various planes (like hyperspace gates in Sci-Fi) you'll end up with 12 differenrt settings instead of one detailed and rich setting.
We can always link any two settings with some sort of magical gate. Strombringer 1st edition suggested something like a gate to Glorantha or the bridge of the Enterprise.
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