I'm planning on doing some kind of survival horror. I'm thinking about using the Resident Evil universe (video games, for sure) for some of my settings.
Btw, I'm surprised I'm not hearing anything about an official Resident Evil P&P role-playing game (this may be due to my ignorance of the rpg business). The games' setting pretty much has everything needed for a full-blown rpg setting--including campaign play. There is even a source book for the setting.
Amazon.com: Resident Evil Archives: BradyGames: Books
With all the mutant beasty madness that you could expect from CoC (but none of the cosmic terror or magic or significant loss of SAN). It would also be a great espionage setting (which is what the background of the story is). All it needs is the BRP rules. It would be a more action oriented version of CoC.
I would also like to do some hard sf games. And maybe a game in a setting like Perfect Dark or Deus Ex.