Suggest (because we can all relate by personal experience) 1 DOSE = 1/2 litre beer, or 0.25-0.3 litres wine, or 0.1 litres strong spirits
Application - Ingestion (really, I think injection calls for specialist rules or GM fiat for an unusual situation)
Onset time - 15 minutes (I'm guessing)
Duration - 2 hours (likewise)
Resistance - Resilience. Adjust Difficulty according to normal rules scale depending on whether you have eaten well, or are starving, or whatever
POTENCY - 40, but +10 cumulative for each extra dose downed within the onset time, and the drinker must reroll for each new application within the duration, again adding + 10 Potency per dose to what's already int he system.
Effects - Put your thoughts here, but as a discussion starter
Potency roll fails - no effect
Potency roll succeeds, Resilience succeeds, no effect, but Potency remains to be added to that of the next drink.
Potency succeeds, Resilience Fails, -10% to skills (including resilience). If you are using Passions - add +10 to the Passion. Potency remains as above.
Potency succeeds, Resilience Fumbles - Puke, pass out, do something embarrassing (scale to Potency already on board). Hangover assumed.
Remember you roll for each dose, and the effects are cumulative.
Not playtested, obviously, this is off the cuff, but similar to my drug use rules. But If I drink 5 pints within 2 hours, and have resilience 50%, succeed/fail/succeed/fail/fail - I'm now -30% on skills, +30% on Passions, Potency in system is now 90% and the next pint will see me home to bed. If I make it. Maybe a bit harsh...but I'll be fine in an hour...no, really, I'm fine to drive...honest.